OROTIC ACID AS A PRECURSOR OF PYRIMIDINES IN THE RAT
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چکیده
منابع مشابه
Orotic acid, a precursor of pyrimidines in the rat.
In recent years erotic acid (uracil-4-carboxylic acid) has been found to be essential for the growth of some microorganisms;l some pyrimidine-requiring Neurospora mutants were found to grow equally well with uracil and erotic acid2 and some mutants have been found to produce erotic acid.3 It has been suggested that erotic acid is a by-product in the biosynthesis of pyrimidines in Neurospora.s I...
متن کاملOrotic acid as a precusor of pyrimidines in the rat.
It was demonstrated by Richardson in 1936 (1) that uracil and guanine were essential for the growth of certain bacteria. Later several investigators found that purines and pyrimidines and corresponding nucleotides are of importance for the metabolism of different microorganisms. Snell and Mitchell (2) established the fact that guanine, adenine, uracil, and thymine may be limiting factors of gro...
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15 صفحه اولThe incorporation of C14-orotic acid into nucleic acid pyrimidines in vitro.
The incorporation in vivo of compounds labeled with N15 or Cl4 into the purines and pyrimidines of nucleic acid has been repeatedly demonstrated (e.g. (l-3)). W e wish to report observations on the incorporation of radioactive erotic acid in vitro into the pyrimidines of the nucleic acid of rat liver slices. It is believed that this procedure will readily permit the study of precursors of nucle...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1949
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56824-1